Broad-spectrum anti-CRISPR proteins facilitate horizontal gene transfer
نویسندگان
چکیده
منابع مشابه
Horizontal Gene Transfer
Horizontal gene transfer (HGT) is the movement of genetic information between organisms, a process that includes the spread of antibiotic resistance genes among bacteria (except for those from parent to offspring), fueling pathogen evolution. Many resistance genes evolved long ago in natural environments with no anthropogenic influence but these genes are now rapidly spreading to and among huma...
متن کاملInferring Horizontal Gene Transfer
Horizontal or Lateral Gene Transfer (HGT or LGT) is the transmission of portions of genomic DNA between organisms through a process decoupled from vertical inheritance. In the presence of HGT events, different fragments of the genome are the result of different evolutionary histories. This can therefore complicate the investigations of evolutionary relatedness of lineages and species. Also, as ...
متن کاملCRISPR interference limits horizontal gene transfer in staphylococci by targeting DNA.
Horizontal gene transfer (HGT) in bacteria and archaea occurs through phage transduction, transformation, or conjugation, and the latter is particularly important for the spread of antibiotic resistance. Clustered, regularly interspaced, short palindromic repeat (CRISPR) loci confer sequence-directed immunity against phages. A clinical isolate of Staphylococcus epidermidis harbors a CRISPR spac...
متن کاملCRISPR-Cas-Mediated Phage Resistance Enhances Horizontal Gene Transfer by Transduction
A powerful contributor to prokaryotic evolution is horizontal gene transfer (HGT) through transformation, conjugation, and transduction, which can be advantageous, neutral, or detrimental to fitness. Bacteria and archaea control HGT and phage infection through CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR-associated proteins) adaptive immunity. Although the benefi...
متن کاملHorizontal gene transfer and phylogenetics.
The initial analysis of complete genomes has suggested that horizontal gene transfer events are very frequent between microorganisms. This could potentially render the inference, and even the concept itself, of the organismal phylogeny impossible. However, a coherent phylogenetic pattern has recently emerged from an analysis of about a hundred genes, the so-called 'core', strongly suggesting th...
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ژورنال
عنوان ژورنال: Nature Microbiology
سال: 2020
ISSN: 2058-5276
DOI: 10.1038/s41564-020-0692-2